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1.
Journal of Pharmaceutical Negative Results ; 14(2):429-435, 2023.
Article in English | EMBASE | ID: covidwho-2230582

ABSTRACT

Background Multisystem involvement of Covid-19 has been known since beginning of the pandemic. Multisystem after-effects or sequelae of covid-19 have been noted and the term 'long Covid' encompasses these signs and symptoms. This leads to prolonged morbidity which have not been adequately addressed by Covid guidelines.The primary aim of our study was to know the spectrum of different sequelae patients have endured after recovery from acute Covid-19 and study their impact on their quality of life. Methods It was a longitudinal observational study of a cohort of 146 patients who recovered from Covid-19 illness. Patients were enrolled within a week of their onset of Covid symptoms and were followed up monthly for a duration of 6 months with a detailed clinical and investigational pulmonary, cardiac, neurological and psychiatric assessment anda final follow-up after a year. Impact on quality of life was assessed using EQ-5D-3L questionnaire. Those lost to follow up were excluded from the analysis. Results 120/146 patients qualified for final analysis. Pulmonary sequelae (40%) were the majority among the patients, followed by psychiatric (25%), neurological (21.7%) and opportunistic infections (5.8%). 4/120 died within a year. 62/120 patients documented worsening in quality of life. Sequelae like pulmonary fibrosis, PTSD had the worst impact on the quality of life.95% severe, 54.5% moderate and 25% mild Covid patients reported deterioration in QoL score respectively. Conclusion Study indicates health related consequences from Covid-19 extend far beyond acute infection andmake significant impact on their quality of life, regardless of the severity of the disease. Copyright © 2023 Wolters Kluwer Medknow Publications. All rights reserved.

2.
Journal of Pharmaceutical Negative Results ; 14(2):429-435, 2023.
Article in English | EMBASE | ID: covidwho-2226809

ABSTRACT

Background Multisystem involvement of Covid-19 has been known since beginning of the pandemic. Multisystem after-effects or sequelae of covid-19 have been noted and the term 'long Covid' encompasses these signs and symptoms. This leads to prolonged morbidity which have not been adequately addressed by Covid guidelines.The primary aim of our study was to know the spectrum of different sequelae patients have endured after recovery from acute Covid-19 and study their impact on their quality of life. Methods It was a longitudinal observational study of a cohort of 146 patients who recovered from Covid-19 illness. Patients were enrolled within a week of their onset of Covid symptoms and were followed up monthly for a duration of 6 months with a detailed clinical and investigational pulmonary, cardiac, neurological and psychiatric assessment anda final follow-up after a year. Impact on quality of life was assessed using EQ-5D-3L questionnaire. Those lost to follow up were excluded from the analysis. Results 120/146 patients qualified for final analysis. Pulmonary sequelae (40%) were the majority among the patients, followed by psychiatric (25%), neurological (21.7%) and opportunistic infections (5.8%). 4/120 died within a year. 62/120 patients documented worsening in quality of life. Sequelae like pulmonary fibrosis, PTSD had the worst impact on the quality of life.95% severe, 54.5% moderate and 25% mild Covid patients reported deterioration in QoL score respectively. Conclusion Study indicates health related consequences from Covid-19 extend far beyond acute infection andmake significant impact on their quality of life, regardless of the severity of the disease. Copyright © 2023 Wolters Kluwer Medknow Publications. All rights reserved.

3.
European Journal of Molecular and Clinical Medicine ; 10(1):4013-4030, 2022.
Article in English | EMBASE | ID: covidwho-2219022

ABSTRACT

Introduction: Covid-19 pandemic has had severe impact on mental health and well-being of people around the globe. The uncountable loss of life, disruption of face-to-face health services and the uncertainty that followed raised concerns over mental health of all people. The impact was much worse in hospitalised covid-19 individuals. Most of the studies done on Covid-19 and mental health were focused on general population and health care workers. In our clinical practise, we observed an increased level of anxiety, stress and depression among hospitalised covid-19 individuals. Hence, we aim to assess the prevalence of psychological distress in these patients and there by validate our observation. Aims and Objectives: To assess the psychological impact of mild to moderate covid-19 disease in hospitalised patients. Material(s) and Method(s): A cross-sectional study was conducted in mild to moderate Covid-19 patients admitted to the tertiary care centre. A total of 501 patients filled 2 questionnaires - Depression, Anxiety, and Stress Scale-21(DASS-21) and Psycho-Social Assessment scale (PSA), a self-structured questionnaire. Result(s): In the depression subscale of DASS-21, 141(28.1%) had mild depression, 101(20.2%) had moderate depression, and 8 (1.6%) had severe depression. In the anxiety subscale, 105(20.9%) had mild anxiety, 198 (39.5%) had moderate anxiety, 35 (7.0%) had severe anxiety and 3 (0.6%) had extremely severe anxiety. In the stress subscale, 132(26.4 %) had mild stress, 161(32.1%) had moderate stress and 51 (10.2%) had severe stress. Patients above 30 years of age had moderate anxiety and stress, with stress being statistically significant among all age groups and gender. There were about 70% prevalence rate in all subgroups in PSA scale with anxiety being highest with 78%. Conclusion(s): The present study is a frontrunner in exploring the spectrum of psychological distress in hospitalised individuals due to Covid-19 disease. The uncertainty that the pandemic has inflicted upon us and its associated social stigma and economic recession has led to widespread increase in stress, anxiety and depression on people, including youngsters. Government, policy-makers and treating physicians should continue to provide mental health evaluation as an essential health service in all covid-19 affected individuals for early risk stratification and prevention of any unfavourable outcome. Copyright © 2022 Ubiquity Press. All rights reserved.

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